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Updated: Aug 25, 2026

Intracellular Refolding Assay
Published on: January 24, 2012
The role of heat-shock proteins as molecular chaperones
1University of California, San Francisco.
Abstract:
Recent studies have revealed that protein folding and assembly events in vivo require the participation of accessory components, now being referred to as 'molecular chaperones'. A number of chaperones have been identified as members of the heat-shock (or stress) protein family. This review discusses the roles of two classes of chaperones, the heat-shock protein 70 and groEL/ES families, in facilitating protein maturation, and describes how such events are perturbed in the cell subjected to metabolic stress.
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