Related Experiment Video
Updated: Aug 6, 2026

Non-invasive Imaging of Disseminated Candidiasis in Zebrafish Larvae
Published on: July 30, 2012
Multifocal choroiditis in disseminated Cryptococcus neoformans infection
Carla Andreola1, Maria P D Ribeiro, Carla R S de Carli
1Department of Ophthalmology, AIDS Section, Centro Previdenciário de Niterói, Rio de Janeiro, Brazil.
Purpose:
To report an uncommon case of multifocal choroiditis as the result of disseminated Cryptococcus neoformans infection in a patient who is HIV-positive.
Design:
Interventional case report.
Methods:
A 27-year-old HIV-positive woman with fever, headache, and vomiting was examined. Lumbar puncture was performed and revealed C neoformans infection. Her condition evolved with sudden bilateral blindness and deafness. Ophthalmologic examination revealed multiple yellowish choroidal lesions in the posterior pole of both eyes.
Results:
Postmortem examination showed disseminated C neoformans infection. Histologic examination of the eyes confirmed the presence of C neoformans in the choroiditis.
Conclusion:
Multifocal choroiditis in C neoformans infection is a rare ophthalmic manifestation. The recognition of this condition by ophthalmologists can help physicians to diagnose a disseminated and fatal disease.
Related Concept Videos
Cryptococcal Meningitis
Fungal Phylum Microsporidia
