Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chlorella viruses.

Takashi Yamada1, Hideki Onimatsu, James L Van Etten

  • 1Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima University, Higashi, Japan.

Advances in Virus Research
|August 1, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Infection cycles of viruses of the phylum Nucleocytoviricota.

Nature reviews. Microbiology·2026
Same author

Taxonomic update for the giant algal chloroviruses of the family Phycodnaviridae.

Archives of virology·2025
Same author

Membrane Composition Modulates Vp54 Binding: A Combined Experimental and Computational Study.

Pathogens (Basel, Switzerland)·2025
Same author

New Isolates of Betachloroviruses Shed Light on the Diversity and Biological Complexity of an Unexplored Group of Giant Algal Viruses.

Viruses·2025
Same author

Modular architecture of K<sup>+</sup> channels: the functional plasticity of the pore module.

EMBO reports·2025
Same author

High life history diversity within a single genus of algal viruses.

The ISME journal·2025
Same journal

Transcriptional regulation of human endogenous retroviruses in cancer.

Advances in virus research·2026
Same journal

Viral threats to pregnancy: Global health risks in the era of pandemics.

Advances in virus research·2026
Same journal

Transforming crop protection: The role of RNAi in mitigating barley yellow dwarf virus and aphid infestation in cereal crops.

Advances in virus research·2025
Same journal

Vertical transmission of tomato viruses.

Advances in virus research·2025
Same journal

Consequences of seed transmission for plant virus emergence.

Advances in virus research·2025
Same journal

The significance of studying high-consequence pathogens in their natural reservoirs.

Advances in virus research·2025
See all related articles

Chlorella viruses, or chloroviruses, are large DNA viruses with complex genomes. Research reveals unexpected viral genes involved in DNA modification, polysaccharide synthesis, and host interactions, suggesting ancient evolutionary origins.

Area of Science:

  • Virology
  • Molecular Biology
  • Genomics

Background:

  • Chloroviruses are large, double-stranded DNA viruses that infect the green alga Chlorella.
  • Paramecium bursaria chlorella virus 1 (PBCV-1) is the prototype virus of the Phycodnaviridae family.
  • These viruses possess complex genomes with numerous protein-encoding genes.

Purpose of the Study:

  • To review research on the structure, genome, gene expression, and evolution of PBCV-1 and related chloroviruses.
  • To highlight unique viral gene products and their functions.
  • To discuss the evolutionary history of these viruses.

Main Methods:

  • DNA sequence analysis of the PBCV-1 genome.
  • Bioinformatic prediction of protein functions.

Related Experiment Videos

  • Review of existing literature on chlorovirus research.

    • Main Results:

    • The 330-kbp PBCV-1 genome encodes approximately 366 proteins, with ~50% having known or unexpected functions.
    • Unique viral gene products include DNA methyltransferases, glycosylation enzymes, a K+ channel (Kcv), and a histone-modifying protein (vSET).
    • PBCV-1 exhibits diverse intron types and possesses features suggesting a long evolutionary history.

    Conclusions:

    • Chloroviruses possess a unique and complex set of genes, distinguishing them from most known viruses.
    • The presence of host-like metabolic and regulatory genes points to a significant evolutionary divergence.
    • Further research into chloroviruses provides insights into viral evolution and host-pathogen interactions.