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Updated: Aug 6, 2026

Protocol for Long Duration Whole Body Hyperthermia in Mice
Published on: August 25, 2012
Molecular aspects of fever and hyperthermia
Joachim Roth1, Christoph Rummel, Stephan W Barth
1Department of Veterinary Physiology, Faculty of Veterinary Medicine, Justus-Liebig-University, Giessen, Germany. Joachim.Roth@vetmed.uni-giessen.de
Abstract:
A rise in core temperature during fever usually results from change in the thermocontroller characteristics, resulting in an elevation of the set point of body temperature. Time course and extent of natural fevers are variable, but an upper limit (41 degrees C in humans), at which core temperature is maintained for some time and reduced when the set point of body temperature returns to its normal level, rarely is exceeded. Although any rise in body temperature may result from fever, those rises that are not accompanied by supportive changes in thermoeffector activities are termed hyperthermia.
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