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Updated: May 3, 2026

Murine Model of Metastatic Liver Tumors in the Setting of Ischemia Reperfusion Injury
Published on: August 30, 2019
Diffuse intraperitoneal metastasis after spontaneous rupture of hepatocellular carcinoma
Chien-Chu Lin1, Chien-Hung Chen, Yuk-Ming Tsang
1Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan. chenhcc@ntumc.org
Abstract:
Rupture of hepatocellular carcinoma (HCC) is a fatal complication. Intraperitoneal metastasis after rupture of HCC is rare. We report a case of diffuse intraperitoneal metastases after rupture of HCC. A previously asymptomatic 32-year-old man was admitted because of massive ascites due to ruptured HCC. Poor liver reserve limited the therapeutic options. Transarterial chemoembolization was performed to stop tumor bleeding. Abdominal computed tomography demonstrated multiple large peritoneal metastases 3 months after the rupture episode. Echo-guided fine needle aspiration from the suprapubic area was performed. Cytology was positive for HCC. It is rare for HCC to develop intraperitoneal metastases in as short as 3 months.

