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Improved efficiency of budesonide nebulization using surface-active agents
A M Bouwman1, M P Heijstra, N C Schaefer
1School of Paediatrics and Child Health, University of Western Australia, Nedlands, West Australia, Australia.
Drug Delivery
|August 1, 2006
Summary
Adding cationic and nonionic detergents significantly improved nebulized budesonide delivery. These surface-active agents enhanced both the emitted dose and respirable fraction of budesonide particles.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
- Aerosol Science
Background:
- Nebulized budesonide is crucial for managing respiratory conditions.
- Optimizing budesonide delivery efficiency is essential for therapeutic efficacy.
- Surface-active agents have the potential to modify aerosol properties.
Purpose of the Study:
- To enhance the efficiency of nebulized budesonide formulations.
- To investigate the impact of various detergents on budesonide aerosol characteristics.
Main Methods:
- Commercial budesonide suspension was modified with cationic, anionic, and nonionic detergents.
- Particle size distribution was analyzed during nebulization using cascade impaction and laser diffraction.
- Emitted dose and respirable fraction were quantified for each formulation.
Main Results:
- Cationic and nonionic detergents significantly increased the emitted dose of budesonide.
- All tested detergent formulations led to a significant increase in the respirable fraction.
- The addition of surface-active agents improved budesonide aerosol performance.
Conclusions:
- Cationic and nonionic detergents effectively enhance the total output of nebulized budesonide.
- Detergent formulations improve the respirable fraction, potentially increasing lung deposition.
- Surface-active agents represent a promising strategy for optimizing budesonide nebulization.
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