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Published on: April 6, 2017
Improved efficiency of budesonide nebulization using surface-active agents
A M Bouwman1, M P Heijstra, N C Schaefer
1School of Paediatrics and Child Health, University of Western Australia, Nedlands, West Australia, Australia.
Abstract:
Our aim was to improve the efficiency of nebulised budesonide using surface-active agents. Cationic, anionic, and nonionic detergents were added to commercial budesonide suspension, and the particle size distribution during nebulization was measured using both cascade impaction and laser diffraction. Our results showed that the emitted dose was increased after addition of cationic (p < 0.001) and nonionic detergents (p < 0.01) compared with the commercial formulation alone. The respirable fraction was increased for all detergent formulations (p < 0.001) compared with the commercial formulation. We concluded that cationic and nonionic detergent increased the total output of budesonide from the Sidestream. All detergent formulations increased the respirable fraction of nebulized budesonide.
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