Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Conjugated estrogens and hypercoagulability.

E von Kaulla, W Droegemueller, K N von Kaulla

    American Journal of Obstetrics and Gynecology
    |July 15, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Relationships between molecular size and shape and physiological effects.

    Experientia·2010
    Same author

    Tackling thrombo-embolism and the relationship of the problem to the surgical hazard.

    Schweizerische medizinische Wochenschrift·2010
    Same author

    Synthetic folic acid in macrocytic anemia.

    Deutsche medizinische Wochenschrift (1946)·2010
    Same author

    Considerations for postnarcotic fibrinolysis.

    Schweizerische medizinische Wochenschrift·2010
    Same author

    Clinical experience reported by candidates for the American Board of Obstetrics and Gynecology 1995 and 1997 oral examinations.

    American journal of obstetrics and gynecology·2001
    Same author

    A faculty development course in obstetrics and gynecology.

    American journal of obstetrics and gynecology·2000
    Same journal

    Association of Surgical Approach with Oncologic Outcomes in Low-Risk Cervical Cancer.

    American journal of obstetrics and gynecology·2026
    Same journal

    Trends in Infertility Treatments by Race, Ethnicity, Socioeconomic Status, and Region in U.S. Birth Certificates from Live Births: 2011-2022.

    American journal of obstetrics and gynecology·2026
    Same journal

    Likelihood ratios enhance clinical interpretation of metagenomic prediction of early-onset neonatal sepsis in preterm premature rupture of membranes (Letter-to-the-Editor).

    American journal of obstetrics and gynecology·2026
    Same journal

    Taking risk stratification in preterm premature rupture of membranes to the bedside (Reply to Letter-to-the-Editor).

    American journal of obstetrics and gynecology·2026
    Same journal

    Gestational Age at Full-Term Delivery and Long-Term Offspring Morbidity in Low-Risk Pregnancies: A Population-Based Cohort Study.

    American journal of obstetrics and gynecology·2026
    Same journal

    Trajectories of childbirth-related posttraumatic stress symptoms after a vaginal delivery: a multicenter prospective study.

    American journal of obstetrics and gynecology·2026
    See all related articles

    Conjugated estrogens in menopausal women showed a slight shift toward hypercoagulability, indicated by thrombelastograms. Antithrombin III activity decreased less than with oral contraceptives, with some fibrin monomers appearing early in therapy.

    Area of Science:

    • Endocrinology
    • Hematology
    • Thrombosis Research

    Background:

    • Menopausal hormone therapy, including conjugated estrogens, is widely used.
    • Estrogen therapy's impact on coagulation and thrombosis risk requires ongoing investigation.
    • Understanding these effects is crucial for patient safety and treatment decisions.

    Purpose of the Study:

    • To assess the procoagulant effects of conjugated estrogens in postmenopausal women.
    • To compare the impact of conjugated estrogens on coagulation parameters with oral contraceptives.
    • To evaluate changes in thrombin generation, fibrinolysis, and thrombelastograms.

    Main Methods:

    • 11 menopausal women received 1.25 mg daily of conjugated estrogens (Premarin).
    • Coagulation tests, including thrombelastograms and euglobin lysis time, were performed after 5 and 21 days.

    Related Experiment Videos

  • Antithrombin III activity and fibrin monomers were also measured.

    • Main Results:

    • A shift toward hypercoagulability was observed in thrombelastogram parameters.
    • No significant changes in thrombin generation or euglobin lysis time were detected.
    • Antithrombin III activity showed a less pronounced decrease compared to oral contraceptives.
    • Fibrin monomers were detected in some participants during the first week.

    Conclusions:

    • Conjugated estrogen therapy may induce a mild hypercoagulable state in some menopausal women.
    • The procoagulant effect appears less potent than that of oral contraceptives.
    • Further research is needed to fully elucidate the long-term thrombotic risk associated with conjugated estrogens.