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Related Experiment Videos

Early neonatal streptococcal infection.

Krishnamoorthy Niduvaje1, Chinnadurai Amutha, Joseph Roy

  • 1Department of Neonatology, National University Hospital, Singapore. kniduvaje@hotmail.com

Indian Journal of Pediatrics
|August 1, 2006
PubMed
Summary

Early onset Group B Streptococcal (GBS) infection incidence in newborns is low. Sepsis evaluation and management effectively prevent GBS septicemia and death in infants born to GBS-colonized mothers.

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Area of Science:

  • Neonatal infections
  • Pediatric infectious diseases
  • Maternal-fetal medicine

Background:

  • Group B Streptococcal (GBS) colonization in mothers poses a risk for early-onset neonatal infections.
  • Effective strategies are crucial to prevent GBS sepsis in newborns.

Purpose of the Study:

  • To determine the incidence of early-onset GBS infection in infants.
  • To evaluate the outcomes of sepsis management in infants born to GBS-colonized mothers.

Main Methods:

  • Retrospective chart review of infants born to GBS-colonized mothers.
  • Analysis of sepsis evaluation, management, and microbiology records.
  • Calculation of incidence rates for culture-proven and probable GBS sepsis.

Main Results:

  • One case of culture-proven GBS septicemia occurred out of 4636 live births (0.2/1000).
  • 88% of infants born to GBS-colonized mothers received sepsis evaluation and empirical penicillin.
  • Two cases of probable sepsis were identified, both in preterm infants; no deaths occurred.

Conclusions:

  • The incidence of early-onset GBS sepsis is low compared to prior studies.
  • Current sepsis evaluation and management protocols are effective in preventing GBS septicemia and mortality in high-risk infants.

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