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Pedimune in recurrent respiratory infection and diarrhoea--the Indian experience--the pride study
1Merck Ltd, Mumbai, India.
Insights
Bovine colostrum significantly reduced recurrent upper respiratory tract infections (URTIs) and diarrhea in children. This natural supplement also lowered hospitalization rates, demonstrating its effectiveness in improving children's health.
Area of Science:
- Pediatrics
- Immunology
- Gastroenterology
Background:
- Recurrent upper respiratory tract infections (URTIs) and diarrhea pose significant health challenges in children.
- Prophylactic strategies are crucial for managing frequent infections and improving pediatric well-being.
Purpose of the Study:
- To assess the efficacy and tolerability of bovine colostrum for preventing recurrent URTIs and diarrhea in children.
- To evaluate the impact of bovine colostrum on hospitalization rates and overall health status.
Main Methods:
- A 12-week study involving 605 children (aged 1-8 years) with recurrent URTIs or diarrhea.
- Participants received bovine colostrum (Pedimune), with assessments of infection episodes, hospitalization, well-being, and adverse events every 4 weeks.
Main Results:
- Significant reductions in URTI episodes (91.19%) and diarrhea (86.60%) were observed post-therapy.
- Pediatricians reported high to average improvement in overall well-being for 96% of patients.
- Patients/caretakers rated overall well-being as very good to good in 90.56% of cases.
Conclusions:
- Bovine colostrum is highly effective for the prophylactic treatment of recurrent URTIs and diarrhea in children.
- The use of bovine colostrum led to a notable decrease in infection episodes and related hospitalizations.
Objective:
To evaluate the efficacy and tolerability of bovine colostrum in preventing recurrent episodes of upper respiratory tract infections and diarrhoea in children
Methods:
605 children (1-8 yrs) having recurrent episodes of upper respiratory tract infections or diarrhea received Bovine Colostrum (Pedimune) for 12 weeks. Total no of episodes of recurrent infections, hospitalization rate, overall well being and adverse events were assessed at every 4 weeks.
Results:
Episodes of URTI and diarrhoea reduced significantly by 91.19 % and 86.60% at the end of therapy respectively. High to average improvement in overall well-being in 96 % of the patients were found by pediatrician while overall well-being stated by the patient/care taker was very good to good in 90.56 % of the patients.
Conclusion:
Bovine colostrum was highly effective in the prophylactic treatment of recurrent URTIs and diarrhea in reducing not only the episodes but also the hospitalization due to them.
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