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Updated: Aug 6, 2026

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
Sleep apnea
Sameer Kumar V Nanaware1, D Gothi, J M Joshi
1Department of Respiratory Medicine, Topiwala National Medical College, B.Y.L.Nair Charitable Hospital, Mumbai Central, Mumbai, India.
Insights
Sleep disordered breathing (SDB) affects 41% of children suspected of having it. Craniofacial abnormalities are a leading cause of obstructive sleep apnea (OSA), with surgical correction improving outcomes.
Area of Science:
- Pediatric Pulmonology
- Sleep Medicine
- Otolaryngology
Background:
- Sleep disordered breathing (SDB) is a spectrum of disorders affecting children.
- Identifying causative factors is crucial for effective management.
Purpose of the Study:
- To investigate the clinical presentation of SDB in children.
- To determine the underlying causes of SDB.
- To evaluate treatment responses in pediatric SDB patients.
Main Methods:
- Retrospective review of clinical data and polysomnography results.
- Analysis of 56 pediatric patients under 18 years of age.
- Baseline and post-therapy polysomnography data were assessed.
Main Results:
- SDB was diagnosed in 41% of the studied children.
- Craniofacial abnormalities were the most common cause (52.1%), followed by neuromuscular/skeletal disorders (17.3%).
- Surgical correction improved SDB in craniofacial and adenotonsillar hypertrophy cases. Positive airway pressure (PAP) was effective for OSA due to vocal cord palsy, scoliosis, and systemic disorders.
Conclusions:
- Pediatric SDB prevalence was 41% in suspected cases.
- Craniofacial abnormalities are a primary cause of OSA in children.
- Surgical and PAP treatments show efficacy for specific SDB etiologies in children.
Objective:
To study clinical presentation of sleep disordered breathing (SDB) in children, their causative factors and response to treatment.
Methods:
A retrospective study of clinical data nd results of overnight polysomnography done at baseline and after therapy were reviewed in 56 patients under 18 years of age.
Results:
Of the 56 patients included in the study 23(41%) cases were positive for SDB. 12 (52.1 %) patients had craniofacial abnormalities, 4 (17.3%) had neuromuscular and skeletal disorders, 2 (8.6%) had adenotonsillar hypertrophy, 1(4.3%) had bilateral vocal cord palsy and 3 (13%) had sleep apnoea associated with multisystemic disorders. Post-operative data showed improvement in all 6 cases of craniofacial abnormalities and both cases of adenotonsillar hypertrophy. Positive airway pressure treatment was useful in cases with obstructive sleep apnea (OSA) due to vocal cord palsy, thoracic scoliosis, systemic disorders and central hypoventilation.
Conclusion:
41% of suspected cases were detected to have SDB. Craniofacial abnormality was the leading cause of OSA in the present study. Surgical correction improved symptoms apnea-hypopnea index (AHI) and desaturation in cases of craniofacial disorders and adenotonsillar hypertrophy. Vocal cord palsy, thoracic scoliosis, hypoventilation and systemic disorders associated OSA responded to positive airway pressure ventilation.
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