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Effects of poor glucose handling on arterial stiffness and left ventricular mass in normal children

F Khan1, H Kerr, R A Ross

  • 1Vascular Diseases Research Unit, The Institute of Cardiovascular Research, Ninewells Hospital and Medical School, Dundee, UK. f.khan@dundee.ac.uk

International Angiology : a Journal of the International Union of Angiology
|August 1, 2006
PubMed

Insights

Children with poorer glucose handling show early signs of arterial stiffening and potential links between blood pressure, body mass index, and left ventricular enlargement, indicating early cardiovascular disease risk.

Area of Science:

  • Pediatric Cardiology
  • Metabolic Health
  • Vascular Physiology

Background:

  • Cardiovascular risk factors are increasingly recognized in pediatric populations.
  • Previous research indicated abnormal microvascular function in children with glucose intolerance and insulin resistance.
  • This study investigates left ventricular mass (LVM) and arterial stiffness in relation to glucose handling in children.

Purpose of the Study:

  • To assess left ventricular mass (LVM) and arterial stiffness in children with varying glucose tolerance.
  • To determine if impaired glucose handling is associated with cardiac and vascular abnormalities.
  • To explore early indicators of cardiovascular disease predisposition in youth.

Main Methods:

  • Echocardiography was used to measure heart dimensions and LVM.
  • Pulse wave analysis was employed to assess arterial stiffness.
  • Participants included 23 children with normal glucose tolerance and 21 with impaired glucose tolerance.

Main Results:

  • Children with poorer glucose handling exhibited slightly shorter pulse wave reflection times, suggesting increased arterial stiffness (P=0.04).
  • A significant relationship between intraventricular septal thickness, blood pressure, and body mass index was observed in the poorer glucose handling group.
  • No such relationships were found in the normal glucose handling group.

Conclusions:

  • Children with lower glucose tolerance demonstrate early signs of arterial stiffening.
  • Emerging associations between blood pressure, BMI, and LVM are noted in this group.
  • These findings may represent early evidence of cardiovascular disease predisposition in children.
Abstract

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