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Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
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Published on: October 12, 2017

The role of high-density lipoprotein cholesterol in atherothrombosis

Brian G Choi1, Gemma Vilahur, Juan F Viles-Gonzalez

  • 1Cardiovascular Biology Research Laboratory, Zena and Michael A. Wiener Cardiovascular Institute, Box 1030, Mount Sinai School of Medicine, One East 100 th Street, New York, NY 10029, USA.

The Mount Sinai Journal of Medicine, New York
|August 1, 2006
PubMed

Insights

Coronary heart disease (CHD) is a leading cause of death. While low high-density lipoprotein (HDL) is a risk factor, therapies to raise HDL for CHD prevention are still under development.

Area of Science:

  • Cardiovascular Medicine
  • Pharmacology

Background:

  • Coronary heart disease (CHD) remains a leading cause of mortality globally.
  • Low high-density lipoprotein (HDL) cholesterol levels are linked to increased CHD risk.
  • Current therapeutic strategies for CHD have limitations, and HDL-raising therapies are not yet standard.

Purpose of the Study:

  • To review the current understanding of high-density lipoprotein (HDL) in atherosclerosis.
  • To discuss the challenges and potential of raising HDL as a therapeutic strategy for coronary heart disease (CHD).
  • To explore emerging pharmacologic approaches for potent HDL elevation.

Main Methods:

  • Review of existing literature on HDL, atherosclerosis, and lipid-lowering therapies.
  • Analysis of the effects of current drugs on HDL and other lipids.
  • Discussion of basic science findings on HDL's beneficial roles.

Main Results:

  • Available HDL-raising drugs also impact other lipids, complicating assessment of HDL's independent effect.
  • Basic science research indicates multiple protective functions of HDL.
  • Development of novel drugs with potent HDL-elevating capabilities is ongoing.

Conclusions:

  • Despite challenges, raising HDL holds promise for managing atherosclerotic diseases.
  • Future pharmacologic advancements may establish HDL elevation as a standard treatment for CHD.
  • Further research is needed to fully elucidate and leverage HDL's therapeutic potential in cardiovascular disease.

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