Related Experiment Video

Updated: Aug 2, 2026

Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

[Idiopathic retroperitoneal fibrosis (Ormond's disease)]

T Nelius1, F Reiher, T Lindenmeir

  • 1Klinik für Urologie, Otto-von-Guericke-Universität Magdeburg, Leipziger Strasse 44, D-39120 Magdeburg. thomas.nelius@medizin.uni-magdeburg.de

Aktuelle Urologie
|August 1, 2006
PubMed
Abstract

Insights

Idiopathic retroperitoneal fibrosis (RPF) is a rare inflammatory condition causing ureteral obstruction. Steroid therapy alongside urinary diversion can lead to RPF regression, reserving surgery for refractory cases.

Area of Science:

  • Nephrology
  • Urology
  • Inflammatory Diseases

Background:

  • Idiopathic retroperitoneal fibrosis (RPF) is a rare inflammatory condition characterized by extensive retroperitoneal fibrosis.
  • Progressive fibrosis can compress retroperitoneal structures, leading to ureteral obstruction and potential renal damage.
  • The unknown etiology of RPF contributes to a lack of consensus regarding optimal treatment strategies.

Observation:

  • A 60-year-old patient presented with flank pain, hydronephrosis, and a retroperitoneal mass.
  • CT-guided biopsy confirmed idiopathic retroperitoneal fibrosis.
  • The patient underwent endoluminal urinary diversion for hydronephrosis.

Findings:

  • Simultaneous administration of steroids resulted in near-complete regression of retroperitoneal fibrosis.
  • Urinary diversion is crucial for protecting renal function in RPF cases.
  • Steroid therapy demonstrated significant efficacy in managing RPF progression.

Implications:

  • Early urinary diversion is paramount for preserving kidney function in RPF.
  • Corticosteroid therapy offers a viable conservative treatment option for RPF, potentially inducing complete regression.
  • Surgical intervention should be reserved for cases of RPF refractory to medical management.

More Related Videos

A Retrograde Implantation Approach for Peritoneal Dialysis Catheter Placement in Mice06:27

A Retrograde Implantation Approach for Peritoneal Dialysis Catheter Placement in Mice

Published on: July 20, 2022

Rectal Organoid Morphology Analysis (ROMA): A Diagnostic Assay in Cystic Fibrosis07:56

Rectal Organoid Morphology Analysis (ROMA): A Diagnostic Assay in Cystic Fibrosis

Published on: June 10, 2022

Related Concept Videos

Types of Intermediate Filaments01:31

Types of Intermediate Filaments

The intermediate filaments are an essential component of the cytoskeleton. Presently six types of intermediate filament have been identified. Type I and II are acidic and basic keratin proteins. Type III is of mesodermal origin and comprises four proteins: vimentin, desmin, glial fibrillary acidic protein (GFAP), and peripherin. Vimentin is commonly found in mesenchymal cells, desmin in muscle cells, GFAP in astrocytes, while peripherin is found in peripheral nervous system neurons (PNS). Type...
Smooth Endoplasmic Reticulum01:21

Smooth Endoplasmic Reticulum

Smooth endoplasmic reticulum or smooth ER is a sub-organelle with specialized functions in animal cells and plant cells. It is often associated with the tubule morphology of the endoplasmic reticulum.
The ER provides optimal conditions for synthesizing steroid hormones and lipids, such as phospholipids and triglycerides. Traditionally, lipid metabolism was considered to be a smooth ER function. However, there is no direct evidence to prove that rough ER is completely excluded from lipid...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
Appendicitis01:19

Appendicitis

Appendicitis is an acute inflammatory condition of the vermiform appendix, most commonly caused by obstruction of its lumen. The appendix is a narrow, blind-ended pouch that extends from the cecum, making it particularly prone to obstruction. Causes include fecaliths, lymphoid hyperplasia (often after viral infections), parasites, tumors, or foreign bodies. This obstruction initiates a cascade of pathological changes.Luminal Obstruction and Early InflammationAfter obstruction, normal mucosal...