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Updated: Aug 6, 2026

Routine Screening Method for Microparticles in Platelet Transfusions
Published on: January 31, 2018
Quality improvement to decrease specimen mislabeling in transfusion medicine
1Department of Laboratory Medicine, Boston University Medical Center, Boston, Mass 02118, USA. kq@bu.edu
Context:
Proper specimen identification and labeling is a critical preanalytic step in pretransfusion compatibility testing.
Objective:
To gather baseline data for specimen mislabeling, specifically targeting major mislabeling events, and to design and implement a plan of corrective action.
Design:
All mislabeled specimens received by the transfusion service for a type and screen were recorded and classified into minor and major mislabeling categories. Major mislabeling events were tracked by origin of the specimen. Locations with a high proportion of major mislabeling were given timely feedback (within 1 week) of the events as they arose.
Setting:
A university hospital.
Main Outcome Measures:
The incidence of major mislabeling.
Results:
The incidence of mislabeling in the transfusion service was 0.5% (243/49 955) during 21 months of data collection. Of these mislabeling events, 47% were classified as major events (unlabeled, mismatched specimen/ requisition, ABO/Rh result on current specimen not matching historical record on file). The emergency department accounted for a high proportion of these major mislabeling events. After the intervention of providing weekly feedback to emergency department staff, their contribution to major mislabeling fell from 47% in 1 year (23/49) to 14% (4/29) in the subsequent 3 quarters.
Conclusions:
Collecting and trending data on mislabeled samples with timely feedback to patient care areas can change phlebotomy practice and reduce specimen mislabeling.
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