Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Haptoglobin polymorphism in patients with preeclampsia.

Herman T Depypere1, Michel R Langlois, Joris R Delanghe

  • 1Women's Clinic, Ghent University Hospital, Ghent, Belgium.

Clinical Chemistry and Laboratory Medicine
|August 2, 2006
PubMed
Summary

Haptoglobin (Hp) polymorphism, specifically the Hp 1-1 phenotype, is more common in preeclampsia patients. This phenotype is linked to more severe hypertension and proteinuria in these women.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Renal Tubular Epithelial Cells as Central Hubs of Kidney Disease.

Diagnostics (Basel, Switzerland)·2026
Same author

Special Issue: "Molecular Mechanisms and Regulation in Chronic Kidney Diseases".

International journal of molecular sciences·2026
Same author

The Ethical Aspects of AI in Scientific Publishing.

EJIFCC·2026
Same author

Pharmacological treatment of presbyopia.

Acta clinica Belgica·2026
Same author

Validation study of the Helena V8 UltraCE capillary elecrophoresis analyser.

Clinical chemistry and laboratory medicine·2026
Same author

Vitamin D binding protein polymorphism is associated with body weight in females.

Hormone molecular biology and clinical investigation·2025

Area of Science:

  • Obstetrics and Gynecology
  • Genetics
  • Cardiovascular Research

Background:

  • Haptoglobin (Hp) polymorphism is implicated in blood pressure regulation and essential hypertension.
  • Previous research suggests a link between Hp and cardiovascular health, warranting investigation in pregnancy-specific conditions.

Purpose of the Study:

  • To investigate the association between haptoglobin (Hp) polymorphism and preeclampsia.
  • To determine if specific Hp phenotypes correlate with clinical markers of preeclampsia severity.

Main Methods:

  • Prospective follow-up of 60 Caucasian women with preeclampsia.
  • Serum Hp phenotypes (1-1, 2-1, 2-2) determined via starch gel electrophoresis.
  • Comparison of Hp phenotypes with 200 normotensive controls; analysis of blood pressure and laboratory markers in relation to Hp phenotypes.

Related Experiment Videos

Main Results:

  • Higher Hp1 allele frequency observed in preeclamptic patients (0.517) compared to controls (0.400).
  • Hp 1-1 phenotype found in 28% of preeclamptic patients versus 16% of controls (OR 2.08).
  • Hp 1-1 phenotype associated with significantly higher systolic and diastolic blood pressure and proteinuria.

Conclusions:

  • The Hp1 allele is more frequent in women with preeclampsia.
  • The Hp 1-1 phenotype is a potential marker for more severe hypertension and proteinuria in preeclampsia.