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Related Experiment Videos

Computed tomography urography for diagnosing bladder cancer.

Benjamin W Turney1, Jonathan M G Willatt, David Nixon

  • 1Department of Urology, The Churchill Hospital, Oxford, UK.

BJU International
|August 2, 2006
PubMed
Summary

Computed tomography urography (CTU) accurately detects bladder tumors in patients over 40 with hematuria. This imaging tool can serve as a reliable first-line screening, potentially reducing the need for cystoscopy.

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Area of Science:

  • Urology
  • Radiology
  • Oncology

Background:

  • Macroscopic haematuria in patients over 40 necessitates prompt and accurate diagnosis of bladder tumours.
  • Current diagnostic pathways may involve multiple invasive procedures.

Purpose of the Study:

  • To evaluate the diagnostic accuracy of computed tomography urography (CTU) for bladder tumours.
  • To assess CTU's utility as a first-line screening tool in high-risk patients.

Main Methods:

  • 200 patients (>40 years, macroscopic haematuria) underwent same-day CTU and flexible cystoscopy.
  • CTU and cystoscopy findings were scored independently and compared with histopathology.
  • CTU sensitivity, specificity, and predictive values were calculated.

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Main Results:

  • Bladder tumour prevalence was 24%.
  • CTU demonstrated high diagnostic accuracy: sensitivity 0.93, specificity 0.99.
  • Positive predictive value was 0.98, and negative predictive value was 0.97.

Conclusions:

  • CTU is an accurate and reliable method for detecting bladder tumours in this patient cohort.
  • CTU can be utilized as a first-line screening tool, potentially streamlining patient assessment.
  • Implementing CTU could lead to a 'one-stop' clinic, reducing the need for flexible cystoscopy in select cases.