Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pediatric antiphospholipid syndrome.

Rolando Cimaz1, Elodie Descloux

  • 1Département de Pédiatrie, Pavillon S, Hopital Edouard Herriot, 69437, Lyon, France. Roland.Cimaz@chu-lyon.fr

Rheumatic Diseases Clinics of North America
|August 2, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A novel STING variant triggers endothelial toxicity and SAVI disease.

The Journal of experimental medicine·2024
Same author

Contribution of rare and predicted pathogenic gene variants to childhood-onset lupus: a large, genetic panel analysis of British and French cohorts.

The Lancet. Rheumatology·2024
Same author

Gender differences in juvenile systemic sclerosis patients: Results from the international juvenile scleroderma inception cohort.

Journal of scleroderma and related disorders·2023
Same author

Clonally expanded PD-1-expressing T cells are enriched in synovial fluid of juvenile idiopathic arthritis patients.

European journal of immunology·2023
Same author

Pediatric Recurrent Pericarditis: Appropriateness of the Standard of Care and Response to IL-1 Blockade.

The Journal of pediatrics·2022
Same author

Correction to: Semiquantitative classification (SQC) and Oxford classifications predict poor renal outcome better than The International Study of Kidney Disease in Children (ISKDC) and Haas in patients with IgAV nephritis: a multicenter study.

Journal of nephrology·2022

Pediatric Antiphospholipid Syndrome (APS) presents unique challenges due to the absence of typical adult risk factors. Research is ongoing to understand its distinct clinical features and optimize treatment for children, including neonatal cases.

Area of Science:

  • Pediatric Rheumatology
  • Autoimmune Diseases
  • Thrombosis

Background:

  • Antiphospholipid Syndrome (APS) is rare in children, lacking common adult risk factors like atherosclerosis or hypertension.
  • Infectious processes are more frequent in children, potentially leading to transient antiphospholipid antibodies (aPL).
  • Neonatal APS, caused by transplacental aPL transfer, serves as a unique in vivo model of acquired autoimmune disease.

Purpose of the Study:

  • To highlight the unique diagnostic and monitoring considerations for pediatric APS.
  • To emphasize the distinct clinical manifestations and risk factors in childhood APS.
  • To discuss the challenges and ongoing research in pediatric and neonatal APS management.

Main Methods:

  • Review of existing literature and international registries for pediatric and neonatal APS.

Related Experiment Videos

  • Analysis of epidemiological, clinical, and laboratory data to understand disease characteristics.
  • Evaluation of treatment strategies, particularly anticoagulation, in the pediatric population.

    • Main Results:

    • Pediatric APS exhibits different clinical presentations and risk factor profiles compared to adults.
    • Neonatal APS demonstrates the direct impact of maternally acquired aPL on newborns.
    • Current treatment approaches for pediatric APS are generally less aggressive, with caution regarding long-term anticoagulation.

    Conclusions:

    • Pediatric APS requires tailored diagnostic and monitoring strategies.
    • Further research is crucial to elucidate the pathophysiology and optimize treatment for pediatric and neonatal APS.
    • Determining the appropriate type and duration of anticoagulation in children is a key area for future studies.