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Paternal age and spontaneous abortion.

K Kleinhaus1, M Perrin, Y Friedlander

  • 1Epidemiology Department, Mailman School of Public Health, Columbia University, New York, New York 10032, USA. krk6@columbia.edu

Obstetrics and Gynecology
|August 2, 2006
PubMed
Summary

Paternal age significantly influences spontaneous abortion risk. Younger fathers (<25) had lower risk, while older fathers (≥40) faced increased odds of spontaneous abortion, independent of maternal factors.

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Area of Science:

  • Reproductive Epidemiology
  • Maternal-Fetal Medicine
  • Genetics

Background:

  • Paternal age is an understudied factor in reproductive outcomes.
  • Previous research has not fully elucidated the independent impact of paternal age on spontaneous abortion risk.

Purpose of the Study:

  • To investigate the association between paternal age and the risk of spontaneous abortion.
  • To determine if this association persists after controlling for maternal age and other confounding variables.

Main Methods:

  • A population-based case-control study utilizing data from the Jerusalem Perinatal Study (1964-1976).
  • Included 1,506 women with spontaneous abortion and 12,359 controls with live births in their previous pregnancy.
  • Logistic regression analysis adjusted for maternal age, parity, smoking, diabetes, and prior spontaneous abortions.

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Main Results:

  • Pregnancies conceived with fathers younger than 25 years showed a reduced odds ratio (0.59) for spontaneous abortion compared to fathers aged 25-29 years.
  • Paternal age of 40 years or older was associated with an increased odds ratio (1.6) for spontaneous abortion compared to the reference group.
  • These associations remained significant after adjusting for multiple maternal and pregnancy-related factors.

Conclusions:

  • Increasing paternal age is a significant risk factor for spontaneous abortion.
  • The influence of paternal age on spontaneous abortion is independent of maternal age and other known risk factors.
  • This finding highlights the importance of considering paternal age in reproductive health assessments.