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Iridoids from Neopicrorhiza scrophulariiflora and their hepatoprotective activities in vitro
Hao Wang1, Fei-Hua Wu, Fei Xiong
1Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, P.R. China.
Chemical & Pharmaceutical Bulletin
|August 2, 2006
Abstract:
Four new non-glycosidic iridoids, piscrocins D (1), E (2), F (6), and G (7), as well as two new iridoid glycosides, piscrosides A (8) and B (9), were isolated from the roots of Neopicrorhiza scrophulariiflora (Scrophulariaceae), together with seven known iridoids. The structures of the isolated compounds were established by means of 1D and 2D NMR spectroscopy and chemical methods. The hepatoprotective activities of these compounds were evaluated by measuring their effects on CCl(4)-induced hepatocytes damage in vitro, and the structure-activity relationships were also discussed.