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Updated: Aug 6, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Synthesis of potential biologically active 1,2-benzothiazin-3-yl-quinazolin-4(3H)-ones
Muhammad Zia-ur-Rehman1, Jamil Anwar Choudary, Saeed Ahmad
1Applied Chemistry Research Center, PCSIR Laboratories Complex, Lahore-54600, Pakistan. rehman_pcsir@hotmail.com
Abstract:
A series of potential biologically active 2-(4-hydroxy-1,1-dioxido-2H-1,2-benzothiazin-3-yl)quinazolin-4(3H)-ones was synthesized in a straight forward manner by condensation of respective 4-hydroxy-1,2-benzothiazine-1,1-dioxides with anthranilamide followed by simple and high throughput cyclization of N-[2-(aminocarbonyl)phenyl]-4-hydroxy-1,2-benzothiazine-3-carboxamide-1,1-dioxides. All the synthesized compounds were subjected to preliminary evaluation for their biological activity against Gram positive and Gram negative bacteria. Some of the assayed compounds showed marked activity against Bacillus subtilis.
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