Morphometric study of gender differences with regard to age-related changes in the C57BL/6 mouse kidney
Akira Yabuki1, Shin Tanaka, Mitsuharu Matsumoto
1Laboratory of Veterinary Anatomy, Department of Veterinary Medicine, Faculty of Agriculture, Kagoshima University, 1-21-24 Korimoto, Kagoshima 890-0065, Japan.
Abstract:
To investigate gender differences with regard to age-related changes in the mouse kidney, kidneys from male and female C57BL/6Cr mice were morphometrically examined at 2, 4, 12, 27 and 33 months of age. Gender differences were clearly observed in age-related changes in renal corpuscle diameter, in addition to semiquantitative scores of glomerular damage and interstitial fibrosis. A greater relative increase in renal corpuscle diameter was observed in females compared to males, and scores indicating glomerular damage and interstitial fibrosis were more severe in males than in females.
