Related Experiment Video
Updated: Aug 6, 2026

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries
Published on: March 31, 2019
CtIP, a multivalent adaptor connecting transcriptional regulation, checkpoint control and tumor suppression
1Department of Biological Chemistry, University of California, Irvine, California, USA.
Abstract:
CtIP was originally characterized as an interacting protein for the transcriptional corepressor CtBP. In addition to transcriptional regulation, CtIP plays an important role in the DNA damage response and cell cycle checkpoint control. Recent evidence points to a viral factor-like S phase promoting activity of CtIP in counteracting Rb repression to facilitate E2F-directed transactivation during the G(1)/S transition. Genetic studies in mice revealed the haploid insufficiency of CtIP in suppressing tumorigenesis associated with shortened life span. Thus, CtIP emerges as a multivalent adaptor that connects cell cycle checkpoint control, transcriptional regulation and tumor suppression.
More Related Videos
Related Concept Videos
Master Transcription Regulators
Cancer-Critical Genes II: Tumor Suppressor Genes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes II: Tumor Suppressor Genes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Interactions Between Signaling Pathways
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Co-activators and Co-repressors
TGF - β Signaling Pathway

