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Related Experiment Videos

Chemogenomics: drug discovery's panacea?

Edgar Jacoby1

  • 1Novartis Institutes for Bio Medical Research, Lichtstrasse 35, Basel, CH-4056, Switzerland. edgar.jacoby@pharma.novartis.com

Molecular Biosystems
|August 2, 2006
PubMed
Summary

Chemogenomics systematically identifies molecules targeting genomic products for drug discovery. This review covers knowledge-based strategies, highlighting challenges and opportunities in early drug discovery and lead optimization.

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Area of Science:

  • Genomics
  • Pharmacology
  • Drug Discovery

Background:

  • Chemogenomics systematically identifies small molecules modulating genomic product functions.
  • Historically focused on target families like kinases, it now integrates knowledge-based principles for target validation and lead optimization.

Purpose of the Study:

  • To summarize knowledge-based chemogenomics strategies.
  • To outline challenges and opportunities impacting drug discovery.

Main Methods:

  • Review of current knowledge-based chemogenomics strategies.
  • Analysis of challenges and opportunities in early drug discovery.

Main Results:

  • Chemogenomics employs systematic approaches to identify bioactive small molecules.
  • Knowledge-based strategies are increasingly used in early drug discovery for target validation and lead identification.
  • High expectations for chemogenomics contrast with high attrition rates in drug discovery.

Conclusions:

  • Chemogenomics offers valuable strategies for drug discovery despite challenges.
  • Future opportunities lie in refining knowledge-based approaches to improve success rates and reduce attrition.

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