Related Experiment Video
Updated: Aug 6, 2026
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Assembly and Characterization of Polyelectrolyte Complex Micelles
Published on: March 2, 2020
Modeling of icodextrin in PD Adequest 2.0
Edward F Vonesh1, Kenneth O Story, Caroline E Douma
1Statistics, Epidemiology and Surveillance, Baxter Healthcare Corporation, Route 120 & Wilson Road, Round Lake, Illinois 60073, USA. voneshe@baxter.com
Summary
A modified three-pore model accurately predicts fluid transport during long peritoneal dialysis exchanges with 7.5% icodextrin. This validated model aids in understanding fluid shifts for patients undergoing icodextrin dialysis treatments.
Area of Science:
- Nephrology
- Biomedical Engineering
- Pharmacokinetics
Background:
- Peritoneal dialysis (PD) fluid transport is complex.
- Accurate modeling is crucial for optimizing PD therapy.
- Icodextrin solutions are used for long dwell exchanges.
Purpose of the Study:
- To validate a modified three-pore model.
- To predict fluid transport during 7.5% icodextrin exchanges.
- To assess model accuracy for net ultrafiltration (UF) and intraperitoneal volume.
Main Methods:
- Nonrandomized, repeated measures study with 10 PD patients naive to icodextrin.
- 8-hour exchanges using 7.5% icodextrin with Dextran 70 as a volume marker.
- Modeled and measured net UF and intraperitoneal volumes using concordance correlation coefficients.
Main Results:
- Strong agreement (concordance correlation = 0.9856) between modeled and measured net UF.
- The modified three-pore model accurately predicted net UF.
- PD Adequest software implemented the validated model.
Conclusions:
- The modified three-pore model accurately predicts net UF and intraperitoneal volumes for long dwell icodextrin exchanges.
- Model validation supports its use in clinical practice.
- Steady-state icodextrin levels are important for chronic users' UF prediction.
