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Failure of dopexamine to protect the hypoxemic newborn rabbit kidney
T Jaton1, M Thonney, J P Guignard
1Service de Pédiatrie, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
Developmental Pharmacology and Therapeutics
|January 1, 1991
Abstract:
The renal effects of dopexamine, a new dopaminergic agonist devoid of any alpha-adrenergic effect, were studied in 11 anesthetized newborn rabbits undergoing an acute hypoxemic normocapnic stress. Acute hypoxemia (PaO2 = 41 mm Hg) was associated with a marked increase in renal vascular resistance and a consequent decrease in glomerular filtration rate and renal blood flow. These changes were not modified by the administration of dopexamine at 10 micrograms/kg/min. Failure of dopexamine to blunt the hypoxemia-induced vaso-constriction suggests vascular dopaminergic receptor immaturity.