[Action of somatostatin (SRIF) on circulation and its interaction with the adrenergic system in rats]

An effect of somatostatin on arterial blood pressure, isolated heart, and its interaction with adrenergic system have been studied in rats. It was found, that somatostatin does not exert any significant effect on blood circulation. It modifies however catecholamines action. Somatostatin decreases the activity of alpha-adrenergic receptors agonist (norepinephrine), and potentiates the activity of beta-adrenergic receptors agonist (isoprenaline).