[Bone metabolic abnormality in diabetes: especially about osteoblast dysfunction]

As for the factor in the diabetes in which it takes part in a bone abnormal metabolism, this is given the insulin lack state, a high blood glucose state, and the complications accompanying diabetes, such as arteriosclerosis, neuropathy, and a renal dysfunction. The absolute, and/or relative insulin lack state deteriorate the function and reduce the number of osteoblast, in addition, the osteoblast dysfunction is also caused by the sorbitol accumulation brought in the osteoblast as the result of the continuation of high blood glucose state. It also prompts the osteoclastic bone absorption, and suppresses the expression of transcription factor gene that regulates the osteoblast differentiation, and resultantly, the apoptosis of the osteoblast is promoted. By these mechanisms intertwining, the differentiation and the maturity of the osteoblast is thought to be decrease and the bone formation process is obstructed.