[Negative correlation between BMD and HbA1C in patients with type 2 diabetes]
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Yasato Komatsu1, Takafumi Majima
1Kyoto University Graduate School of Medicine, Department of Medicine and Clinical Science.
Abstract:
This study included 145 patients with type 2 diabetes, and 95 non-diabetic control. We measured bone mineral density (BMD) at the sites with different cortical/cancellous bone ratio (lumbar spine, femoral neck, and distal radius). BMD and Z score at the distal radius were significantly lower in type 2 diabetic patients than those in control subjects. In type 2 diabetic patients, negative correlation between BMD and the mean HbA(1C) during the last 2 years was found significantly at the distal radius in both sexes. These results indicate the selective cortical bone loss in type 2 diabetes, and suggest the importance of evaluating BMD at the radius as well and keeping good metabolic control to prevent bone loss in type 2 diabetic patients.
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