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Delayed Intramyocardial Delivery of Stem Cells after Ischemia Reperfusion Injury in a Murine Model
Published on: September 3, 2020
[Ischemic cardiomyopathy: remote complications and their prognostication after isolated myocardial revascularization]
Insights
Cardiovascular complications after aorto-coronary grafting (ACG) affect 40% of ischemic cardiomyopathy patients within a year. Left ventricular ejection fraction and end-systolic diameter are key predictors of these remote cardiac events.
Area of Science:
- Cardiology
- Cardiac Surgery
- Echocardiography
Background:
- Ischemic cardiomyopathy poses significant risks for cardiovascular complications post-aorto-coronary grafting (ACG).
- Predicting long-term outcomes after ACG in these patients remains a clinical challenge.
Purpose of the Study:
- To determine the rate of remote cardiovascular complications after ACG in patients with ischemic cardiomyopathy.
- To identify pre- and early postoperative markers of left ventricular (LV) function for prognosis.
Main Methods:
- Doppler echocardiography assessed LV function pre- and post-surgery in 170 patients.
- Logistic regression analysis evaluated prognostic markers for cardiovascular events within 1 year.
Main Results:
- The 1-year rate of cardiovascular complications after ACG was 40% in patients with ischemic cardiomyopathy.
- Preoperative and early postoperative LV ejection fraction and deceleration time, along with early postoperative LV end-systolic diameter, were significant prognostic markers (p<0.05).
Conclusions:
- LV function parameters, particularly ejection fraction and deceleration time, are crucial for predicting cardiovascular complications after ACG in ischemic cardiomyopathy.
- Early identification of high-risk patients using echocardiographic markers can guide postoperative management.
Abstract:
Aim of investigation was to study rate of remote cardiovascular complications after aorto-coronary grafting (ACG) in patients with ischemic cardiomyopathy and revelation of informative pre- and early postoperative markers of left ventricular (LV) function for determination of prognosis of cardiovascular complications and functional state of patients in remote postoperative period. Doppler echocardiographical parameters of left ventricular function were assessed in pre- and early postoperative period in 107 patients in whom cardiovascular events did not recur in late postoperative period (during 1 year) and in 63 patients who had recurrent cardiovascular events. Influence of a sign (x) on probability p(x) of cardiovascular events in postoperative period was estimated on the basis of logistic model. Rate of cardiovascular complications during 1 year after ACG in patients with ischemic cardiomyopathy was 40%. Most significant prognostic markers of cardiovascular complications in remote postoperative period were LV ejection fraction and deceleration time of early filling before surgery and in early postoperative period, as well as LV end systolic diameter in early postoperative period (p<0.05).
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