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Updated: Aug 6, 2026
Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia
Published on: October 17, 2025
Severe acute hypertriglyceridemia during acute lymphoblastic leukemia induction successfully treated with
Vita Ridola1, Paola Sabrina Buonuomo, Palma Maurizi
1Department of Pediatric Oncology, Catholic University of Rome, Rome, Italy. vita.ridola@rm.unicatt.it
Abstract:
Children suffering from Acute Lymphoblastic Leukaemia (ALL) treated with asparaginase and corticosteroids are at risk of developing severe lipid abnormalities. The authors report the case of a 10-year-old male with extremely high plasma triglyceride concentrations (4,000 mg/dl) during the induction phase of ALL associated with mild pancreatitis. Hypertriglyceridemia was successfully managed with plasmapheresis with a decrease in triglyceride levels to 590 mg/dl. Apheresis appears to be safe and effective in reducing hypertriglyceridemia and preventing related complications.