Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Effect of hydrodynamic environment on tablet dissolution using flow-through dissolution apparatus.

Yan Wu1, Evone S Ghaly

  • 1School of Pharmacy, University of Puerto Rico, San Juan.

Puerto Rico Health Sciences Journal
|August 4, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dynamic expression of DKK1 protein in the process whereby Epimedium-derived flavonoids up-regulate osteogenic and down-regulate adipogenic differentiation of bone marrow stromal cells in ovariectomized rats.

Orthopaedic surgery·2011
Same author

Extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase pathway is involved in inhibition of myogenic differentiation of myoblasts by hypoxia.

Experimental physiology·2011
Same author

Scaling law for energy-momentum spectra of atomic photoelectrons.

Optics express·2011
Same author

The changing seroepidemiology of enterovirus 71 infection among children and adolescents in Singapore.

BMC infectious diseases·2011
Same author

The persistent circulation of enterovirus 71 in People's Republic of China: causing emerging nationwide epidemics since 2008.

PloS one·2011
Same author

[Research of the essential oil of Plumeria rubra var. actifolia from Laos by supercritical carbon dioxide extraction].

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials·2011
Same journal

The Current State of Home Health Care in Puerto Rico.

Puerto Rico health sciences journal·2026
Same journal

Reasons for Regimen Modifications of Antineoplastic Agents in an Outpatient Oncology Clinic in Puerto Rico.

Puerto Rico health sciences journal·2026
Same journal

Characterizing Sleep and Physical Activity Patterns Among Adults in Puerto Rico with Inflammatory Bowel Disease.

Puerto Rico health sciences journal·2026
Same journal

Biologic Therapy for Psoriasis and Risk of Malignancies in a Hispanic Population: A Single Center Retrospective Cohort.

Puerto Rico health sciences journal·2026
Same journal

Prognostic Value of the Mini Nutritional Assessment, Key Biomarkers, and Body Mass Index for Mortality in Acute Ischemic Stroke.

Puerto Rico health sciences journal·2026
Same journal

Experiences of Violence Among Puerto Rican Women Before, During and After Pregnancy: Prevalence and Associated Health Factors using Data from the Puerto Rico Pregnancy Risk Assessment Monitoring System.

Puerto Rico health sciences journal·2026
See all related articles

Drug dissolution rate is influenced by hydrodynamic conditions like flow rate and apparatus type. An equation was developed to predict drug release from conventional tablets.

Area of Science:

  • Pharmaceutical Sciences
  • Physical Chemistry
  • Chemical Engineering

Background:

  • Understanding drug dissolution is crucial for predicting in vivo performance.
  • Hydrodynamic conditions significantly impact drug release from solid dosage forms.
  • Existing models may not fully capture the influence of fluid dynamics on dissolution.

Purpose of the Study:

  • Investigate principles of drug dissolution.
  • Study drug release phenomena in laminar flow.
  • Determine the effect of hydrodynamic conditions on drug dissolution to predict release from solid dosage forms.

Main Methods:

  • Formulated theophylline (Class I) and naproxen (Class II) into conventional tablets and hydroxypropylmethylcellulose (HPMC) matrices.
  • Tested dissolution using USP II and IV apparatus with varying cell diameters, flow rates, and tablet positions.

Related Experiment Videos

  • Developed a predictive equation for drug dissolution from conventional tablets.

    • Main Results:

    • Increased flow rate enhanced drug release.
    • Smaller cell diameter and horizontal tablet position in USP IV apparatus led to faster dissolution.
    • Hydrodynamic conditions did not affect HPMC matrix tablet dissolution, indicating matrix control.
    • Established a predictive equation: Sh=-21.36+10.58Re(1/2) (R²=0.98) for conventional tablets.

    Conclusions:

    • Hydrodynamic conditions and dissolution apparatus type influence dissolution rate, mass transfer, and film thickness.
    • Drug release from HPMC matrices is primarily matrix-controlled, independent of hydrodynamics.
    • The developed equation provides a tool for predicting drug dissolution from conventional tablets.