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Published on: July 5, 2021
Integrated 18F-fluorodeoxyglucose positron emission tomography and computerized tomography in endodermal sinus tumor
C Klieger1, R Dvir, E Even-Sapir
1Department of Obstetrics and Gynecology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel.
Summary
Positron emission tomography-computed tomography (PET-CT) effectively images endodermal sinus tumors (ESTs). This diagnostic tool accurately assesses tumor extent and confirms successful treatment by detecting (18)F-fluorodeoxyglucose (FDG) uptake.
Area of Science:
- Oncology
- Nuclear Medicine
- Radiology
Background:
- Endodermal sinus tumor (EST) is a rare germ cell tumor.
- Accurate staging and treatment monitoring are crucial for EST management.
- Positron emission tomography-computed tomography (PET-CT) utilizes (18)F-fluorodeoxyglucose (FDG) for metabolic imaging.
Observation:
- Two cases of EST in young females are presented.
- Elevated alpha-fetoprotein (AFP) levels were noted in both patients.
- PET-CT demonstrated increased FDG uptake in tumor sites, indicating active disease.
Findings:
- PET-CT accurately delineated the extent of EST, including peritoneal seeding.
- Post-treatment PET-CT scans showed no significant FDG uptake, correlating with disease remission.
- EST was confirmed as an FDG-avid tumor, responsive to chemotherapy.
Implications:
- PET-CT is a valuable tool for staging and evaluating treatment response in EST.
- The study highlights the utility of FDG-PET-CT in managing rare pediatric and young adult malignancies.
- Serial PET-CT imaging can help rule out residual disease after therapy.
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