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Related Experiment Videos

Primate-specific evolution of an LDLR enhancer.

Qian-fei Wang1, Shyam Prabhakar, Qianben Wang

  • 1Genomics Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA. QFWang@lbl.gov

Genome Biology
|August 4, 2006
PubMed
Summary
This summary is machine-generated.

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Researchers found a new regulatory element in primates that changed how the low-density lipoprotein receptor works. This discovery explains how gene regulation evolves and impacts species differences.

Area of Science:

  • Evolutionary biology
  • Genomics
  • Molecular biology

Background:

  • Regulatory sequence changes are proposed drivers of species phenotypic divergence.
  • However, concrete molecular evidence for this has been scarce.

Purpose of the Study:

  • To identify molecular mechanisms of regulatory evolution in primates.
  • To investigate the evolution of the low-density lipoprotein receptor (LDLR) regulatory regions.

Main Methods:

  • Comparative genomics using conserved and divergent primate species.
  • In vivo and in vitro functional assays.
  • Sequence analysis of regulatory elements.

Main Results:

  • An anthropoid primate-specific sequence element was identified.

Related Experiment Videos

  • This element contributed to the regulatory evolution of the LDLR.
  • A functional cholesterol-sensing motif emerged and was fixed in anthropoid primate ancestors within an existing enhancer.

    • Conclusions:

    • Demonstrates a molecular mechanism for the evolution of mammalian regulatory elements.
    • Highlights how ancestral elements can acquire new functions in the primate lineage.
    • Provides insight into the genetic basis of phenotypic divergence.