Online coupling of solid-phase microextraction and capillary electrophoresis
Related Experiment Video
Updated: Feb 27, 2026

Amplification of Escherichia coli in a Continuous-Flow-PCR Microfluidic Chip and Its Detection with a Capillary Electrophoresis System
Published on: November 21, 2023
1Department of Chemistry, Nanjing University, Nanjing 210093, China. zhenliu@nju.edu.cn
Abstract:
Solid-phase microextraction (SPME) and capillary electrophoresis (CE) are two of the main inventions that shaped 20th Century analytical chemistry. SPME is an effective microscale sampling and sample preparation technique, and CE is a high-efficiency microanalytical method. Online coupling of SPME with CE can be a powerful combination because of the significant advantages of the two techniques. The progress in the development of online SPME-CE coupling is surveyed in this review. Problems encountered and solutions reported are highlighted.
Related Concept Videos
Capillary Electrophoresis: Applications
Capillary zone electrophoresis (CZE) separates ionic components based on their electrophoretic mobility. It has been used to separate proteins, amino acids,...
Electrophoresis: Overview
There...
Capillary Electrophoresis: Instrumentation
High-Performance Liquid Chromatography: Elution Process
Size-Exclusion Chromatography
Silica particles offer advantages such as rigidity,...
Ion-Exchange Chromatography

