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Online coupling of solid-phase microextraction and capillary electrophoresis.
1Department of Chemistry, Nanjing University, Nanjing 210093, China. zhenliu@nju.edu.cn
Journal of Chromatographic Science
|August 4, 2006
Summary
Online coupling of solid-phase microextraction (SPME) and capillary electrophoresis (CE) offers significant advantages in analytical chemistry. This review surveys progress, problems, and solutions in developing this powerful combination.
Area of Science:
- Analytical Chemistry
- Separation Science
Background:
- Solid-phase microextraction (SPME) is a key microscale sampling and sample preparation technique.
- Capillary electrophoresis (CE) is a high-efficiency microanalytical method.
- Both SPME and CE are significant 20th-century analytical chemistry innovations.
Purpose of the Study:
- To review the progress in the development of online SPME-CE coupling.
- To highlight challenges and their reported solutions in integrated SPME-CE systems.
Main Methods:
- Survey of literature on online SPME-CE coupling.
- Analysis of advancements and reported issues in the field.
Main Results:
- Online SPME-CE coupling combines the strengths of both techniques.
- Significant progress has been made in developing and optimizing online SPME-CE systems.
- Various problems encountered in coupling have been addressed with effective solutions.
Conclusions:
- The online coupling of SPME and CE is a powerful analytical strategy.
- Continued development in this area promises further advancements in microscale analytical techniques.
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