Related Experiment Videos
High-throughput evaluation of non-swellable controlled release matrix tablets
R Panchagnula1, A Gupta, S Kandavilli
1Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER) Sector 67, S.A.S. Nagar, Punjab, India. r.panchagnula@ulster.ac.uk
Drug Development and Industrial Pharmacy
|August 4, 2006
Summary
A new method measures water permeation and drug release from controlled-release (CR) matrix tablets simultaneously. This high-throughput technique uses tritiated water (HTO) and correlates well with drug release, offering a surrogate marker for CR tablet evaluation.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
- Materials Science
Background:
- Controlled-release (CR) matrix tablets rely on water permeation and diffusion for drug release.
- Evaluating CR matrix tablets traditionally involves dissolution testing, which can be resource-intensive.
Purpose of the Study:
- To propose a novel methodology for measuring water permeation and simultaneous drug release from inert, non-swellable CR matrix tablets.
- To establish a correlation between water permeation and drug release processes.
- To evaluate the proposed method as a high-throughput alternative for CR tablet assessment.
Main Methods:
- Cylindrical CR matrix tablets of diltiazem (DLT) were prepared via extrusion-spheronization and direct compression.
- Water transport was quantified using tritiated water (HTO) in a Franz-diffusion cell.
- Simultaneous drug release and HTO permeation were measured over 24 hours.
- Comparative dissolution studies were conducted using USP apparatus I.
Main Results:
- Matrices exhibited steady water uptake for up to 6 hours.
- A steady state for HTO permeation was observed between 6 and 24 hours.
- A strong correlation was found between the flux of permeated water and the flux of released drug.
Conclusions:
- HTO permeation through CR matrix tablets can serve as a reliable surrogate marker for drug release.
- The proposed methodology offers a high-throughput, resource-efficient approach for evaluating controlled-release matrix tablets compared to traditional dissolution testing.