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Preparation of Hydroxy-PAAm Hydrogels for Decoupling the Effects of Mechanotransduction Cues
Published on: August 28, 2014
Controlled release by permeability alteration of cationic ammonio methacrylate copolymers using ionic interactions
H Ravishankar1, P Patil, A Samel
1Degussa India Pvt Ltd., Research Centre India, Mumbai, India. hema.ravishankar@degussa.com
Drug Development and Industrial Pharmacy
|August 4, 2006
Summary
This study explores a multiparticulate drug delivery system for theophylline. Modulating polymer interactions with specific anions like succinate and acetate can control drug release, offering a new controlled drug delivery option.
Area of Science:
- Pharmaceutical Sciences
- Polymer Chemistry
- Drug Delivery Systems
Background:
- Controlled drug delivery systems aim to optimize therapeutic efficacy and patient compliance.
- Multiparticulate systems offer advantages in dose uniformity and reduced variability.
- Ammonio methacrylate polymers are widely used in pharmaceutical formulations.
Purpose of the Study:
- To investigate a multiparticulate drug delivery system for modulating theophylline release.
- To evaluate the impact of ammonio methacrylate polymer interactions with various anions on drug release kinetics.
- To assess the influence of polymer layer thickness on in vitro drug release profiles.
Main Methods:
- Development of a multiparticulate system with an anionic core, drug layer, and polymer coatings (EUDRAGIT NE and EUDRAGIT RS).
- In vitro drug release studies were conducted using theophylline as a model drug.
- Systematic variation of anions (chloride, succinate, citrate, acetate) and polymer layer thickness.
Main Results:
- Succinate and acetate anions demonstrated permeability-enhancing effects on the polymer matrix.
- Citrate and chloride anions exhibited permeability-retarding effects.
- Polymer layer thickness significantly influenced the drug release rate.
Conclusions:
- The interaction between ammonio methacrylate polymers and specific anions can effectively modulate drug release.
- The developed multiparticulate system shows potential for creating customized drug release profiles.
- This system represents a viable alternative for developing advanced controlled drug delivery technologies.
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