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Published on: March 25, 2020
MMP-2 assessment as an indicator of wound healing: A feasibility study
Refaat B Karim1, Beatriz L R Brito, Richard P Dutrieux
1Department of Plastic and Reconstructive Surgery, Onze Lieve Vrouwe Gasthuis, Amsterdam, the Netherlands.
Objective:
Evaluate the feasibility of assessment of fibroblast matrix metalloproteinase-2 (MMP-2) expression as an indicator of wound healing in wounds that change from chronically inert to actively healing.
Methods:
Phase II feasibility study of 4 patients with nonhealing wounds (duration, > or = 3 months; surface area, > or = 1 cm). Wounds were treated with a dressing impregated with oak bark extract (DerMax) and evaluated weekly; biopsies were performed every 2 weeks until wound healing.
Results:
Therapy-induced wound healing and immunohistochemical measurements of MMP-2 expression paralleled the clinical characteristics of wound healing.
Conclusion:
MMP-2 expression offers a reliable indicator for clinical wound healing induced by DerMax treatment.
