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Nutritional hormesis.

D P Hayes1

  • 1New York City Department of Health and Mental Hygiene, New York, NY 10007, USA. dhayes@health.nyc.gov

European Journal of Clinical Nutrition
|August 4, 2006
PubMed
Summary
This summary is machine-generated.

Hormesis, a concept where low doses have opposite effects to high doses, is relevant to nutrition. This review establishes its significance in nutritional science and guidelines.

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Area of Science:

  • Toxicology
  • Nutritional Science
  • Biology

Background:

  • The concept of hormesis, where low doses of a substance can elicit opposite effects compared to high doses, is a key toxicological principle.
  • This review focuses on the implications and evidence of hormesis within the field of nutrition.

Purpose of the Study:

  • To review the concept of hormesis and its relevance to nutrition.
  • To categorize and discuss dose-response relationships, including hormetic effects.
  • To present evidence supporting nutritional hormesis.

Main Methods:

  • Literature review and synthesis of existing research on hormesis.
  • Categorization and depiction of various dose-response relationships.
  • Examination of proposed mechanisms underlying hormetic effects.

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Main Results:

  • Evidence for nutritional hormesis is presented for essential nutrients, dietary restriction, alcohol, and various dietary compounds like pesticides and acrylamide.
  • Hormetic and other dose-response relationships are categorized and discussed.
  • Proposed hormetic mechanisms are reviewed.

Conclusions:

  • The relevance and validity of hormesis in nutrition are established.
  • The study discusses the potential roles of hormesis in advancing nutritional research and informing nutritional guidelines.