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Related Experiment Videos

[Serotonin transporter gene polymorphism in slow transit constipation].

Jian-hua Ding1, Chuan-gang Fu, Rong-hua Zhao

  • 1Department of Colorectal Surgery, Changhai Hospital, The Second Military Medical University, Shanghai 200433, China. junyi93@yahoo.com.cn

Zhonghua Wei Chang Wai Ke Za Zhi = Chinese Journal of Gastrointestinal Surgery
|August 4, 2006
PubMed
Summary

The short allele (S) of the serotonin transporter gene-linked polymorphic region (5-HTTLPR) is associated with slow transit constipation (STC). This genetic variation may play a role in the development of STC.

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Area of Science:

  • Genetics
  • Gastroenterology
  • Molecular Biology

Background:

  • Slow transit constipation (STC) is a functional gastrointestinal disorder characterized by delayed colonic transit.
  • The serotonin transporter gene (SERT) plays a crucial role in regulating gastrointestinal motility.
  • Polymorphisms in the serotonin transporter gene-linked polymorphic region (5-HTTLPR) may influence SERT expression and function.

Purpose of the Study:

  • To investigate the association between the 5-HTTLPR polymorphism and the risk of developing STC.
  • To determine if specific 5-HTTLPR genotypes are more prevalent in patients with STC compared to healthy controls.

Main Methods:

  • Genotyping of the 5-HTTLPR polymorphism using polymerase chain reaction (PCR).
  • Study included 54 patients diagnosed with STC and 100 healthy controls.

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  • Analysis of genotype frequencies in relation to STC diagnosis, gender, age, and colonic transit parameters.

    • Main Results:

    • The short/short (S/S) genotype and the S allele of 5-HTTLPR were significantly more frequent in STC patients than in controls (P < 0.05).
    • No significant differences in 5-HTTLPR polymorphism were observed between genders or age groups ( < 45 and >= 45 years).
    • The S/S genotype was more common in STC patients with delayed colonic transit (less than 40% marker evacuation within 72 hours).

    Conclusions:

    • The presence of the 5-HTTLPR allele S is associated with an increased risk of STC.
    • 5-HTTLPR polymorphism may contribute to the pathophysiology of slow transit constipation.
    • This genetic finding could offer insights into the molecular mechanisms underlying STC.