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Updated: Aug 6, 2026

Determination of the Gas-phase Acidities of Oligopeptides
Published on: June 24, 2013
Structural and spectroscopic analysis of hydrogensquarates of glycine-containing tripeptides
Bojidarka B Koleva1, Tsonko M Kolev, Michael Spiteller
1Sofia University St. Kl. Ohridsky Faculty of Chemistry, Department of Analytical Chemistry, 1164 Sofia, Bulgaria.
Abstract:
The hydrogensquarates of glycine-containing tripeptides glycylglycylglycine (H-Gly-Gly-Gly-OH), glycylglycylmethionine (H-Gly-Gly-Met-OH), and methionylglycylglycine (H-Met-Gly-Gly-OH) have been characterized structurally. Quantum chemical ab initio calculations, solid-state linear-dichroic infrared (IR-LD) spectroscopy, 1H and 13C NMR data, ESI-MS, HPLC-MS/MS, TGV, and DSC methods were employed. The structures consist in a positively charged peptide moiety and a negative hydrogensquarate anion (HSq), stabilized by strong intermolecular hydrogen bonds.
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