[Development of Pseudomonas aeruginosa infection in mice with trichinellosis]

The aim of this study was to estimate the development of P. aeruginosa infection in mice infected with T. spiralis or T. pseudospiralis. The investigations were carried out on the following strains of mice: C57Bl, C3H and B6C3F1. 20 days post parasitic infection P.aeruginosa were administrated by inhalation or by intraperitoneal injection. After 4 hrs development of infection in mice was evaluated (the number of bacteria in lung or in the liver tissue were counted by plating). It was found that the bacterial infection developed with the highest rate in C3H mice followed by C57B1/6, in comparison with control mice. In C3H mice infected with T. pseudospiralis, the number of bacteria was higher in lung and liver tissue, in comparison with those infected with T. spiralis. In B6C3F1 hybrid the infection rate was significantly lower after intraperitoneal administration in T. spiralis infected mice. In our experiments, the development of P. aeruginosa infection in mice with trichinellosis was dependent on the strain of mice and the routes of bacteria administration.