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[In vitro resistance of Candida species to antifungal agents]

W Banach-Piatkowska1, A Kotłowski, J Humanowska

  • 1Zakład Medycyny Tropikalnej Instytutu Medycyny Morskiej i Tropikalnej w Gdyni 81-519 Gdynia, ul. Powstania Styczniowego 9b.

Wiadomosci Parazytologiczne
|August 5, 2006
PubMed

Insights

Most Candida species showed susceptibility to polyenes (91.6%) but fewer to azoles (32.9%). Antifungal resistance varied by fungal species and sample type, highlighting the need for susceptibility monitoring.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Clinical Microbiology

Background:

  • Fungal infections caused by Candida species are a significant global health concern.
  • Antifungal resistance is an emerging challenge in treating these infections.
  • Understanding the susceptibility patterns of Candida isolates is crucial for effective treatment strategies.

Purpose of the Study:

  • To evaluate the in vitro susceptibility of clinical Candida isolates to six antifungal agents.
  • To determine the prevalence of resistance to polyenes and azoles among these isolates.
  • To explore the relationship between antifungal susceptibility, fungal species, and clinical sample source.

Main Methods:

  • Analysis of 143 Candida strains isolated from 545 patients suspected of fungal infections.
  • In vitro susceptibility testing using the ATB Fungus (bioMérieux) commercial assay.
  • Categorization of susceptibility based on resistance to polyenes and azoles.

Main Results:

  • High susceptibility (91.6%) was observed for polyenes, while lower susceptibility (32.9%) was noted for azoles against all Candida isolates.
  • Low percentages of resistance were found for polyenes (0.7% to 4.2%), contrasting with higher rates for azoles (32.9% to 41.2%).
  • Antifungal resistance patterns were found to be dependent on the clinical sample source and the specific Candida species.

Conclusions:

  • The study demonstrates significant variations in Candida susceptibility to different antifungal classes.
  • The ATB Fungus test is a valuable tool for monitoring antifungal susceptibility in clinical settings.
  • Tailoring antifungal therapy based on susceptibility data is essential for optimizing patient outcomes.

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