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[How to improve efficacy of onychomycosis treatment?]
1Katedra i Klinika Chorób Skórnych i Wenerycznych AM w Gdańsku, 80-211 Gdańsk, ul Debinki 7.
Abstract:
Onychomycosis is a public health concern because of its high world wide prevalence, and its potential for spread of fungal elements to others. About one half of all patients presenting to dermatologists' offices for nail disorders have onychomycosis. This kind of infection may impact upon physical, functional, and emotional aspects of life. Onychomycosis can be treated with the new generation of oral antifungals. Efficacy rates for fingernail onychomycosis are high; however, for toenail onychomycosis, efficacy rates may range from 60% to 80%. Relapse rates have been estimated to be 15% to 20% measured at 2 years following therapy initiation. Because many factors may be associated with a suboptimal clinical response, consideration to measures that reflect the most appropriate pharmacologic and supportive regimens must be made in order to meet the challenge of onychomycosis cure. In some situations supplemental therapy consisting of extra antifungal or adjunctive (topical/surgical) therapy may be beneficial.
Insights
Onychomycosis, a common nail infection, affects physical and emotional well-being. New oral antifungals offer effective treatment, but optimizing regimens is key to cure and preventing relapse.
Area of Science:
- Dermatology
- Mycology
Context:
- Onychomycosis is a prevalent public health issue.
- Nail disorders are frequently diagnosed as onychomycosis in dermatological settings.
- The infection significantly impacts patients' quality of life.
Purpose:
- To review the current understanding of onychomycosis.
- To discuss treatment strategies for onychomycosis.
- To highlight factors influencing treatment outcomes.
Summary:
- Onychomycosis affects a substantial portion of individuals seeking dermatological care for nail conditions.
- New oral antifungal agents demonstrate high efficacy for fingernail infections, with 60-80% efficacy for toenail onychomycosis.
- Relapse rates range from 15-20% within two years post-treatment initiation.
Impact:
- Effective management of onychomycosis requires consideration of pharmacologic and supportive care.
- Supplemental therapies, including topical or surgical interventions, may enhance treatment outcomes.
- Addressing onychomycosis is crucial for improving patient physical, functional, and emotional health.
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