Related Experiment Videos
Primary osteoblastic osteosarcoma in an elderly female: a case report of perplexing presentation
Eubulus J Kerr1, Pierce D Nunley, David A Cavanaugh
1Spine Institute of Louisiana, Shreveport, Louisiana, USA.
Anticancer Research
|August 5, 2006
Abstract:
With advances in imaging technology and increased alertness by clinicians, the reported incidence of primary vertebral osteosarcoma (PVOS) has increased in recent times and, therefore, the importance of its correct diagnosis has repeatedly been emphasized. One such case of PVOS is reported, that presented with insidious clinical, radiological and pathological findings, resulting in a slightly delayed final diagnosis and treatment.
Related Concept Videos
01:29Bone Disorders
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
01:31Osteoclasts in Bone Remodeling
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...