Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Insulin sensitivity and beta cell function in different glucose tolerance status].

Anel Gómez-García1, Patricia Magaña-Garns, Javier Ruiz-García

  • 1Unidad de Investigación en Epidemiología Clínica, Hospital General Regional No 1, CIBIMI-IMSS, Morelia, México. anel.gomez@imss.gob.mx

Investigacion Clinica
|August 5, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Short- and Middle-Term Nephroprotective and Cardioprotective Effects of Pentoxifylline in Patients with Diabetic Nephropathy: A Randomized Controlled Trial.

Medical sciences (Basel, Switzerland)·2026
Same author

An approximation to the prevalence of focal segmental glomerulosclerosis: A systematic review of world literature over the past 32 years.

Nefrologia·2025
Same author

Retrospective study on the association between paternal occupational exposure to agrochemicals and childhood leukemia in Michoacán de Ocampo, México.

PeerJ·2025
Same author

Clinical Significance of Nuclear Yin-Yang Overexpression Evaluated by Immunohistochemistry in Tissue Microarrays and Digital Pathology Analysis: A Useful Prognostic Tool for Breast Cancer.

International journal of molecular sciences·2025
Same author

May Measurement Month 2022: an analysis of blood pressure screening results from Mexico.

European heart journal supplements : journal of the European Society of Cardiology·2025
Same author

Impact of COVID-19 Vaccination on Hospitalization and Mortality: A Comparative Analysis of Clinical Outcomes During the Early Phase of the Pandemic.

Infectious disease reports·2025
Same journal

Evidences about combination use of acetylsalicylic acid (aspirin) and clopidogrel in acute coronary syndrome.

Investigacion clinica·2018
Same journal

A c.3037G>A mutation in FBN1 gene causing Marfan syndrome with an atypically severe phenotype.

Investigacion clinica·2018
Same journal

Cardio-Metabolic Health Venezuelan Study (EVESCAM): Design and Implementation.

Investigacion clinica·2018
Same journal

Association of high sensitivity C-reactive protein with diet composition in Mexican school children.

Investigacion clinica·2018
Same journal

Prehipertension: influence of psychological stress in adolescents.

Investigacion clinica·2018
Same journal

Inotropic and chronotropic effects of propranolol in isolated atrium of rats with fructose-induced insulin-resistance

Investigacion clinica·2018
See all related articles

This study found that decreased glucose tolerance is linked to lower insulin sensitivity (IS). Beta cell function (BCF) was reduced in type 2 diabetes patients, highlighting the need for early screening in high-risk individuals.

Area of Science:

  • Endocrinology
  • Metabolic Disorders
  • Diabetes Research

Background:

  • Insulin sensitivity (IS) and beta cell function (BCF) are critical for glucose homeostasis.
  • Understanding these parameters across different glucose tolerance statuses is essential for early diabetes detection and prevention.

Purpose of the Study:

  • To comparatively investigate insulin sensitivity (SI) and beta cell function (BCF) in individuals with varying glucose tolerance.
  • To assess the relationship between IS, BCF, and clinical factors like body weight and BMI.

Main Methods:

  • A cross-sectional study involving 84 patients categorized into normoglycemic-control (NC), family history of diabetes (FPDM2), impaired glucose tolerance (IGT), and type 2 diabetes (DM2) groups.
  • Oral glucose tolerance test (OGTT) with glucose and insulin measurements.

Related Experiment Videos

  • Calculation of Insulin Sensitivity Index (Whole Body IS), HOMA for insulin resistance (IR), and insulinogenic index for BCF.

    • Main Results:

    • Insulin levels were significantly higher in FPDM2 and IGT groups compared to NC.
    • Insulin sensitivity (IS) was significantly lower in IGT and DM2 groups compared to NC and IGT respectively.
    • Beta cell function (BCF) was significantly lower in the DM2 group compared to NC, FPDM2, and IGT groups.
    • IS showed an inverse relationship with body weight and BMI.
    • BCF was related to age, glucose AUC, and body weight.

    Conclusions:

    • A decrease in glucose tolerance is associated with reduced insulin sensitivity (IS).
    • Beta cell function (BCF) is notably diminished in patients with type 2 diabetes.
    • Routine assessment of IS and BCF in high-risk individuals is recommended for early identification and intervention to prevent diabetes onset.