Related Experiment Video
Updated: Aug 6, 2026

Large-Scale Multi-Omics Genome-Wide Association Studies (Mo-GWAS): Guidelines for Sample Preparation and Normalization
Published on: July 27, 2021
An integrative approach for the identification of quantitative trait loci
M Arbilly1, A Pisanté, M Devor
1Department of Genetics, Institute of Life Sciences, Hebrew University of Jerusalem, Jerusalem, Israel.
Abstract:
The genetic dissection of complex traits is one of the most difficult and most important challenges facing science today. We discuss here an integrative approach to quantitative trait loci (QTL) mapping in mice. This approach makes use of the wealth of genetic tools available in mice, as well as the recent advances in genome sequence data already available for a number of inbred mouse strains. We have developed mapping strategies that allow a stepwise narrowing of a QTL mapping interval, prioritizing candidate genes for further analysis with the potential of identifying the most probable candidate gene for the given trait. This approach integrates traditional mapping tools, fine mapping tools, sequence-based analysis, bioinformatics and gene expression.
Related Concept Videos
Multiple Allele Traits
Polygenic Traits
Modern Molecular Taxonomy
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
