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t(8;14)(q24;q32) in two patients with CD10-negative primary thyroid diffuse large B-cell lymphoma
Nozomi Niitsu1, Masataka Okamoto, Tadashi Yoshino
1Division of Hematology, Department of Internal Medicine, Saitama Medical University, 38 Morohongo, Moroyama, Iruma-Gun, Saitama, Japan. nniitsu@saitama-med.ac.jp
Leukemia Research
|August 5, 2006
Summary
Two rare cases of primary thyroid diffuse large B-cell lymphoma (DLBCL) with the 8q24 translocation were reported. Both patients achieved remission with conventional therapy, highlighting the need for more research on this rare lymphoma subtype.
Area of Science:
- Oncology
- Hematology
- Genetics
Background:
- Diffuse large B-cell lymphoma (DLBCL) is a common non-Hodgkin lymphoma.
- The 8q24 translocation, specifically t(8;14)(q24;q32), is a hallmark of Burkitt lymphoma but is rarely observed in DLBCL, particularly in the thyroid gland.
Observation:
- This study presents two cases of primary thyroid DLBCL exhibiting the t(8;14)(q24;q32) translocation.
- Case 1: A 66-year-old female with CD10-, CD20+, BCL-2+/add(13)(q34), t(8;14)(q24;q32) immunophenotype and karyotype.
- Case 2: A 70-year-old female with CD10-, CD20-, CD79a+, BCL-2-/t(8;14)(q24;q32) immunophenotype and karyotype.
Findings:
- Both patients achieved long-term complete remission following conventional chemotherapy with or without radiation therapy.
- The study details the distinct immunophenotypic and karyotypic profiles of the two primary thyroid DLBCL cases.
Implications:
- These findings contribute to the limited literature on primary thyroid DLBCL with the 8q24 translocation.
- Further case accumulation is crucial for establishing standardized treatment protocols and understanding the pathogenesis of this rare entity.
- This research may inform future diagnostic and therapeutic strategies for thyroid lymphomas.
