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Related Experiment Videos

Deformable gas-filled microbubbles targeted to P-selectin.

Joshua J Rychak1, Jonathan R Lindner, Klaus Ley

  • 1Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908-0158, USA.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|August 5, 2006
PubMed
Summary

Engineered deformable microbubbles show improved targeting to intravascular disease markers. This enhanced adhesion, due to increased contact area and deformability, offers potential for advanced medical imaging and therapy.

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Cardiovascular Research

Background:

  • Ultrasound contrast microbubbles are used to target intravascular disease markers.
  • Leukocytes deform to adhere to inflamed endothelium, suggesting deformability enhances adhesion.

Purpose of the Study:

  • To improve targeted delivery of microbubbles by enhancing their deformability.
  • To investigate if deformable microbubbles increase adhesion to disease markers.

Main Methods:

  • Lipid-shell microbubbles were targeted to P-selectin using anti-P-selectin antibodies.
  • Deformable microbubbles were created by controlled pressurization, generating wrinkles and folds.
  • Adhesion was assessed in a flow chamber and an in vivo murine inflammation model.

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Main Results:

  • Deformable microbubbles showed significantly better sustained adhesion under shear stress (0.4-1.35 dyn/cm²) compared to wrinkle-free ones.
  • Wrinkled microbubbles deformed in shear flow, unlike wrinkle-free microbubbles.
  • Intravital microscopy revealed improved targeting of deformable microbubbles in a murine model.

Conclusions:

  • Microbubble deformability and surface microstructure are critical for efficient site-targeted delivery.
  • Deformable microbubbles offer enhanced adhesion and targeting for medical imaging and therapy.
  • Mechanical aspects of particle adhesion are key for engineering targeted agents.