Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Congenital localized scleroderma.

Francesco Zulian1, Cristina Vallongo, Sheila Knupp Feitosa de Oliveira

  • 1Department of Pediatrics, University of Padua, Italy. zulian@pediatria.unipd.it

The Journal of Pediatrics
|August 5, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Psoriatic arthritis spectrum in children: a multicentre observational study.

Clinical and experimental rheumatology·2026
Same author

"Adnexotropic" lichen striatus: a potential histological mimicker of mycosis fungoides.

Pathologica·2026
Same author

Systemic Sclerosis Without Raynaud Phenomenon in Children: The Fibrotic Subtype.

The Journal of rheumatology·2026
Same author

Efficacy and Safety of Clascoterone Cream 1% for Acne Are Independent of Age and Sex.

Journal of drugs in dermatology : JDD·2026
Same author

Nailfold videocapillaroscopy in the assessment of juvenile connective tissue diseases.

Clinical and experimental rheumatology·2026
Same author

Recurrent calf myositis as revealing manifestation of Crohn disease: a case report.

Frontiers in pediatrics·2026

Congenital localized scleroderma (CLS) is a rare condition presenting at birth. This rare form of juvenile localized scleroderma (JLS) exclusively shows linear subtypes, often misdiagnosed, necessitating earlier identification.

Area of Science:

  • Pediatric Rheumatology
  • Pediatric Dermatology
  • Neonatology

Background:

  • Juvenile localized scleroderma (JLS) typically manifests in later childhood.
  • Congenital localized scleroderma (CLS) is a rare variant with onset at birth.
  • Understanding CLS is crucial for early diagnosis and management in neonates.

Observation:

  • A multinational study identified 6 cases (0.8%) of CLS among 750 JLS patients.
  • All CLS cases presented with linear scleroderma, four with facial 'en coup de sabre' morphology.
  • Misdiagnosis was common, with delays averaging 3.9 years.

Findings:

  • CLS exhibits a significantly longer disease duration at diagnosis compared to late-onset JLS.
  • The 'en coup de sabre' subtype was more frequent in CLS.

Related Experiment Videos

  • Linear scleroderma was the sole presentation in all studied CLS cases.

    • Implications:

    • CLS is likely underestimated in newborns and requires inclusion in differential diagnoses for infants with skin lesions.
    • Prompt diagnosis of CLS can prevent functional and aesthetic complications.
    • Early therapeutic intervention is vital for managing CLS and mitigating long-term sequelae.