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Updated: Aug 4, 2026

Humanized Mouse Model to Study Bacterial Infections Targeting the Microvasculature
Published on: April 1, 2014
Bacteriology of human bite wound infections
C V Merriam1, H T Fernandez, D M Citron
1R. M. Alden Research Laboratory, 2001 Santa Monica Blvd., Santa Monica, CA 90404, USA. vreni-rmarl@juno.com
Abstract:
This study was designed to define the bacteriology of infected soft-tissue wounds from human bites, and to compare this with the bacteriology of infected animal bites in humans as determined in previous studies. The specimens were collected from 57 patients presenting to emergency rooms at 12 locations around the country. Three hundred and eighty organisms were isolated (224 aerobes and 156 anaerobes), for an average of 6.6 per specimen. The most prevalent anaerobes recovered were Prevotella spp. (34%), while streptococci comprised 44% of all aerobic organisms, over half of which were in the "Streptococcus milleri" group, particularly S. anginosus. The study demonstrated that the pathogens in human bite infections differ considerably from those present in animal bites.
Insights
Human bite wound infections show distinct bacterial profiles compared to animal bites. Prevotella spp. and Streptococcus milleri group bacteria are key pathogens in human bites, differing significantly from animal bite flora.
Area of Science:
- Microbiology
- Infectious Diseases
- Wound Care
Background:
- Bite wound infections pose a significant clinical challenge.
- Understanding the specific microbial etiology is crucial for effective treatment.
- Previous studies have characterized animal bite wound bacteriology, but human bite data is less defined.
Purpose of the Study:
- To delineate the specific bacterial pathogens involved in infected human soft-tissue bite wounds.
- To compare the bacteriology of human bite wounds with that of animal bite wounds.
Main Methods:
- Specimens were collected from 57 patients with infected human bite wounds across 12 emergency room locations.
- Bacterial cultures were performed to isolate and identify aerobic and anaerobic organisms.
- Quantitative analysis of isolated organisms was conducted.
Main Results:
- A total of 380 organisms were isolated, averaging 6.6 per specimen.
- Prevotella spp. were the most common anaerobes (34%).
- Streptococci (44%) were the predominant aerobes, with the Streptococcus milleri group (particularly S. anginosus) being most frequent.
Conclusions:
- The bacterial pathogens identified in human bite wound infections are considerably different from those found in animal bite infections.
- This distinct microbiological profile necessitates tailored therapeutic approaches for human bite wounds.
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